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Losartan microinjects into the hippocampus CA1 region showed an anxiolytic-like effect in bilateral olfactory bulbectomy rats (OBX, rat model of depression), indicating the involvement of Ang II in the pathogenesis of anxiety by activating AT 1 R (42)

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However, conventional oral chemotherapy is significantly hindered by multiple physiological, chemical, microbial, and tumor microenvironment-associated barriers within the GIT of CRC patients

Free radicals are unstable molecules that can originate from environmental factors like pollution and toxins, as well as natural processes such as metabolism